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Design of β-sheet protein with specific binding properties
Design of β-sheet protein with specific binding properties
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机译:具有特异性结合特性的β-折叠蛋白的设计
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摘要
A protein (I) with beta -'leaflet' structure having surface-exposed amino acids, present in at least two surface-exposed beta -strands of a surface-exposed beta -leaflet, is new. The protein is altered by targeted mutagenesis so that it has new, or improved, specific binding, catalytic or fluorescent properties. Independent claims are also included for the following: (1) DNA (II) that encodes (I); (2) RNA (III) derived from (II); (3) prokaryotic and eukaryotic vectors and cells that contain (II) or (III), or their fragments that encode a functional region of (I); and (4) method for producing (I).
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