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IMMUNOMODULATION BY ALTERING SPHINGOSINE 1-PHOSPHATE LYASE (SPL) ACTIVITY
IMMUNOMODULATION BY ALTERING SPHINGOSINE 1-PHOSPHATE LYASE (SPL) ACTIVITY
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机译:通过改变鞘氨醇1-磷酸裂解酶(SPL)活性进行免疫调节
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摘要
Compositions and methods for modulating immune function are provided based on the unexpected discovery that inhibition of sphingosine-1-phosphate lyase (SPL) activity confers useful immunosuppressive effects, for example to modulate immune function in treatment or prevention of inflammation, transplant graft rejection, autoimmune disease, allergy, or other conditions, including therapeutic alteration of immune system cell survival and/or proliferation. Altering SPL activity by direct or indirect pharmacological intervention, or alternatively by molecular genetic methods to alter SPL expression levels, are also contemplated.
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