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Detection and Localized Imaging of Cancer Using X-Ray Fluorescent Nanoparticle/Preferential Locator Conjugates
Detection and Localized Imaging of Cancer Using X-Ray Fluorescent Nanoparticle/Preferential Locator Conjugates
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机译:使用X射线荧光纳米颗粒/优先定位物缀合物检测和局部成像的癌症。
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摘要
A method for detecting gold or other nanoparticles conjugated to preferential locators commences by contacting tissue suspected of being neoplastic with gold nanoparticle/preferential locator conjugates for a time adequate for the conjugates to bind with the tissue. A beam of gamma photons (such as from, 99mTc) is directed at the conjugate bound tissue to remove electrons from the K-shell or L-shell, for example, of the gold nanoparticles. The removed electrons can be detected for locating neoplastic tissue or X-ray fluorescence corresponding to an electron transitioning from one shell to another shell can be detected, or by detecting resulting X-ray fluorescence corresponding to an electron transitioning from one shell to another shell, such as X-ray fluorescence arising from K-alpha emission corresponding to an electron transitioning from the L shell to the K shell. Additional X-ray fluorescing detecting molecules include Ag, I, Fe, Tc, Zn, Mn, Cr (trivalent).
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