Method for the Characterization of the Three-Dimensional Structure of Proteins Employing Mass Spectrometric Analysis and Computational Feedback Modeling

摘要

A method for characterizing the three-dimensional surface structure of molecules, particularly proteins and protein complexes, employing mass spectrometric analysis, an electrospray ionization (ES) source, a novel data interpretation process that utilizes comparisons of particular binding constants (K_B) and heats of formation (ΔH_f), and computational feedback modeling.