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Detecting disease association with aberrant glycogen synthase kinase 3beta expression
Detecting disease association with aberrant glycogen synthase kinase 3beta expression
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机译:检测异常糖原合酶激酶3beta表达与疾病的关系
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摘要
The present invention provides a method for diagnosing a disease or disorder associated with aberrant GSK-3β expression and/or activity or for determining the predisposition of a subject to the disease or disorder. In particular, the methods of the present invention comprise detecting a marker that comprises one or more polymorphisms and/or one or more allelic variants of a glycogen synthase kinase 3β gene. The present invention also relates to a method for identifying new markers that are diagnostic of a disease or disorder associated with aberrant GSK-3β expression and/or activity. Furthermore, the present invention relates to methods of identifying and producing candidate compounds for the treatment of a disease or disorder associated with aberrant GSK-3β expression and/or activity.
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