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POPULATION SEQUENCING USING SHORT READ TECHNOLOGIES
POPULATION SEQUENCING USING SHORT READ TECHNOLOGIES
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机译:使用短读技术进行人口排序
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摘要
The claimed subject matter provides systems and/or methods that facilitate generating population sequences of strain variants included in a sample. Sequencing can be based on high throughput of short reads. Further, site variants exhibited in the short reads can be linked to reconstruct multiple full strains of a targeted gene, including low concentration variants in the sample. Cues in the short read data can be utilized to perform multi-strain assembly. For example, the cues can include different strain concentrations that lead to more frequently seen strains being responsible for more frequent reads and quilting of overlapping reads to infer mutation linkage over long stretches of DNA.
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