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Polyvinyl Pyrollidone Cryoprecipitate Extraction of Clotting Factors
Polyvinyl Pyrollidone Cryoprecipitate Extraction of Clotting Factors
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机译:聚乙烯吡咯烷酮冷冻沉淀法提取凝血因子
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摘要
Blood collection, processing and transfer leads to the separation of discrete fractions by adding additional citrate (trisodium citrate) to bring the citrate concentration to 10%-15% w/v thereby leading to enhanced yield and purity of cryoprecipitate. The improved cryoprecipitate then yields concentrated clotting factors by an improved extraction process which uses polyvinyl pyrollidone to reduce the extraction of fibrinogen. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds
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