An anatomy-based biomechanic shoe sole comprises an inner arch supporting segment bulging toward a arched human plantar surface, an outer arch supporting segment bulging toward the arched human plantar surface, and a depressed calcaneus supporting segment formed fitting the arched human plantar surface. The aforesaid supporting segments are respectively arranged at an optimum position that is determined through measurement based on foot anatomy so that the supporting segments are effective to mitigate the pressure borne by a human foot and enhance comfort to the human foot in the perspective of biomechanics.
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