首页>
外国专利>
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
展开▼
机译:糖基化人β分泌酶的结晶和结构测定,该酶与阿尔茨海默氏病有关
展开▼
页面导航
摘要
著录项
相似文献
摘要
An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 Å resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
展开▼