Methods of inhibiting leptin-induced signaling with fibronectin III domain antibodies

摘要

The invention relates to a new type of leptin receptor antagonist, which is able to prevent leptin signaling without preventing the binding of leptin to the leptin binding domain. More specifically, the invention relates to the use of a part of the leptin receptor to prevent the leptin-dependent activation of the receptor, and by this the leptin-induced signaling.