首页>
外国专利>
DISEASE DIAGNOSIS BY PROFILING SERUM GLYCANS
DISEASE DIAGNOSIS BY PROFILING SERUM GLYCANS
展开▼
机译:通过分析血清甘油来诊断疾病
展开▼
页面导航
摘要
著录项
相似文献
摘要
Specific glycomic profiles derived from human blood sera of breast cancer patients and prostate cancer patients were compared to those of disease-free females and males, respectively. The profiles were acquired using MALDI-MS of permethylated N-glycans released from 10-μl sample aliquots. Quantitative permethylation was attained using solid-phase permethylation. Principal component analysis of the glycomic profiles revealed significant differences among the two sets (diseased vs. non-diseased), allowing their distinct clustering. Several sialylated and fucosylated N-glycan structures were found to be useful as biomarkers for cancer, particularly breast cancer or prostate cancer.
展开▼