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NANOPARTICLE-BASED IMAGING AGENTS FOR X-RAY/COMPUTED TOMOGRAPHY AND METHODS FOR MAKING SAME

机译:用于X射线/计算机断层扫描的基于纳米粒子的成像剂及其制造方法

摘要

The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
机译:本发明总体上涉及核/壳纳米颗粒,其中这种核/壳纳米颗粒包括纳米颗粒核和围绕纳米颗粒核设置的纳米壳,使得它们在总体上形成核/壳纳米颗粒,其可操作地用作X射线/计算机断层扫描(CT)中的显像剂。通常,这种基于核/壳纳米粒子的X射线CT成像剂还包含用于将成像剂靶向到患病部位的靶向物质。本文包括形成此类试剂的方法,包括形成核/壳纳米颗粒的集合体,其中选择核/壳纳米颗粒的集合体的平均直径,以使该集合体中的纳米颗粒基本上可被哺乳动物的肾脏清除。

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