HETEROLOGOUS PRODUCTION OF NATURAL PRODUCTS IN BACTERIA

摘要

The present invention demonstrates an example of the de novo total biosynthesis of biologically active forms of heterologous NRPs in Escherichia coli (E. coli). The system can serve not only as an effective and flexible platform for large-scale preparation of natural products from simple carbon and nitrogen sources, but also as a general tool for detailed characterizations and rapid engineering of biosynthetic pathways for microbial syntheses of novel compounds and their analogs.