Methods and compositions for regulating proliferation and migration of vascular smooth muscle cells

摘要

Provided is an extracellular domain of a mammalian Fat1 (Fat1_EC). Also provided is an intracellular domain of a mammalian Fat1 (Fat1_IC). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1_EC. A vector comprising a nucleic acid sequence encoding the Fat1_IC is further provided. Also, a vascular stent coated with the Fat1_EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.