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Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
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机译:N端规则泛素化的底物和测量这些底物的泛素化的方法
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摘要
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
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