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Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency
Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency
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机译:具有提高的广度和效力的人免疫缺陷病毒中和人抗体
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摘要
The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
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