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Sustained release tablet containing indapamide

机译:含有吲达帕胺的缓释片剂

摘要

The present invention relates to a sustained release tablet containing indapamide and the process of manufacturing sustained release tablet containing indapamide. The tablet contains indapamide in the amount of 1.5 to 2.5% of the total mass of the tablet, lactose monohydrate in the amount of 30 to 80% of the total mass of the tablet, copovidone in the amount of 2 to 10% of the total mass of the tablet, hypromellose in the amount of 20 to 65% of the total mass of the tablet and lubricants in the amount of 0.1 to 5% of the total mass of the tablet. The process of manufacturing the sustained release tablet consists in mixing of indapamide with lactose monohydrate and copovidone and then, the mixture is moistened by purified water and the granulation process of it is performed. Next the granulate is dried, cooled, mixed with hypromellose and lubricants and compressed in tableting machine.
机译:本发明涉及含有吲达帕胺的缓释片剂和制造含有吲达帕胺的缓释片剂的方法。片剂中的吲达帕胺含量为片剂总质量的1.5%至2.5%,乳糖一水合物的含量为片剂总质量的30%至80%,共聚维酮的含量为总片剂的2%至10%片剂的质量,羟丙甲纤维素的量为片剂的总质量的20%至65%,润滑剂的量为片剂的总质量的0.1%至5%。制备缓释片剂的方法包括将吲达帕胺与乳糖一水合物和共聚维酮混合,然后将混合物用纯净水润湿并制粒。接下来,将颗粒干燥,冷却,与羟丙甲纤维素和润滑剂混合并在压片机中压片。

著录项

  • 公开/公告号US7553499B2

    专利类型

  • 公开/公告日2009-06-30

    原文格式PDF

  • 申请/专利权人 KATARZYNA JURECZEK;

    申请/专利号US20050518386

  • 发明设计人 KATARZYNA JURECZEK;

    申请日2002-07-24

  • 分类号A61K9/26;A61K9/22;

  • 国家 US

  • 入库时间 2022-08-21 19:30:57

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