Reshaped human antibody to human interleukin-6 receptor

摘要

A reshaped human antibody to the human IL-6R, comprising:(A) an L chain comprising, (1) a human L chain C region, and(2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 receptor (IL-6R); and(B) an H chain comprising, (1) a human H chain C region, and(2) an H chain V region comprising human H chain FRS, and mouse H chain CDRs of a monoclonal antibody to the IL-6R.;Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.