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Agents for promoting the proliferation or differentiation of stem cells or neural progenitor cells

机译:促进干细胞或神经祖细胞增殖或分化的药剂

摘要

An agent for promoting the proliferation or differentiation of a stem cell and/or neural progenitor cell, comprising a compound represented by Formula:; wherein each of R1 and R2 is H, a hydrocarbon group or a heterocyclic group, or taken together with the adjacent carbon atom to form a ring, R3 is H, a hydrocarbon group or a heterocyclic group, W is a group represented by Formula: ; wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R4 is an acyl group having an aliphatic hydrocarbon group, which is substituted by an aromatic group and may have a further substitutent, or aromatic group, R5 is H, C1-6 alkyl or acyl, R4c is an aromatic group, an aliphatic hydrocarbon group or acyl, and X is O or S; Y is O, S or NH, Ring C is an optionally substituted benzene ring, or a salt or prodrug thereof is provided.
机译:促进干细胞和/或神经祖细胞增殖或分化的药剂,其包含下式表示的化合物: 其中R 1 和R 2 各自为H,烃基或杂环基,或R 3 是与相邻的碳原子一起形成环的基团,H是烃基或杂环基,W是下式表示的基团: ; 其中,环A为可选取代的苯环,环B为可选取代的5至7元含氮杂环R 4 是具有脂族烃基的酰基,其被芳族基团取代并且可以具有其他取代基或芳族基团,R 5 是H,C 1-6 < / Sub>烷基或酰基,R 4c 是芳族基团,脂肪族烃基或酰基,并且 X是O或S; Y为O,S或NH,C环为可选取代的苯环,或其盐或前药。

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