Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics

摘要

The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I):; in which:R₁ represents a hydrogen atom or a (C₁-C₄)alkyl group;R₂ represents a hydrogen atom or a (C₁-C₄)alkyl group;R₃ represents a thienyl mono- or polysubstituted by a methyl group; or a monocyclic or bicyclic heterocyclic radical chosen from: a pyridyl, an N-oxidopyridinio, a pyrazolyl, an (N-phenyl)pyrazolyl, an (N-halophenyl)pyrazolyl, a furyl, an indolyl, an (N-benzyl)indolyl, an (N-halobenzyl)indolyl, a benzothienyl or a benzofuryl, the said radicals being unsubstituted or substituted one or more times by a halogen atom or a methyl or methoxy group;R₄ and R₅ are identical or different and each independently represent a hydrogen or halogen atom or a hydroxyl, hydroxymethyl, (C₁-C₄)alkyl, trifluoromethyl, C₁-C₄)alkoxy, (C₁-C₄)alkoxycarbonyl or cyano group.;Preparation process and application in therapeutics.