Polycyclic viral Inhibitors, which includes a Pharmaceutical Composition and its use in preparation of drugs for the treatment of a viral infection mediated by hepatitis C virus

摘要

Compounds and components of the transmission formula (1) and their use in the treatment of flavidae family diseases. 1: A Dow or steric endrin (1) or a pharmaceutically acceptable salt characterized by rings h and I being independent of arilo of the six alternative members or heterosexual of the five to six alternative members, Two or three heterocyclic atoms independently selected from n, NH, N-oxidation or s groups; t is a C1-5 tar, one or two CH2 groups can be selectively selected by n-nrc, - S -,The o-o-and the alternative two groups - CH2 - together form a double-sided link, so t does not contain a group - O-O,-S-O-O-SQ selected from cyclopentanediol, cyclopentanediol substitute, cyclopentadiene substitute, cyclopentadiene substitute, heterocyclic substitute, arilo substitute, isopropene substitute, isopropene substitute and isopropene substitute groups; D or E is c-ra, D or D is d or E is s; or D is ch and E is E-CH = ch = Z, D is Z, e. The atoms combined with them form a ring composed of six members, which is combined with the rest of the molecule: module making (2);R is selected independently of the replaced hydrogen, asphalt and asphalt groups; Rb is selected from the halogen, ACIL, acilamin, asphalt, asphalt, replaced asphalt, carbonate, hydroxyl y = O groups; n is 0, 1 or 2; Z is selected from the (a) carboxi and carbonate groups; (b) - C (x4) n8r9, with characteristics Because X4 = O, = NH o = n-alkyl, R8 and R9 are selected independently of the following components: hydrogen, asphalt, tar, alternative asphalt, alternative asphalt, alternative asphalt, alternative asphalt, alternative arilo, alternative arilo, alternative arilo, heterogeneous, alternative heterosexual, alternative, alternative, alternative, or alternative,R8 and R9, together with the nitrogen atoms on their sides, form a heterocycle, an alternative heterocycle, a heterocycle or a group of heterocycles; (c) - G (x3) nr21s (o) 2R4, wherein X3 is selected between = or = Nr24 = s, R24 is the substituted hydrogen, tar or tar; R4 is selected from tar, the substituted tar, Arilo, arilo substitution, heteromorphic, heteromorphic substitution, heterocyclic substitution, and nr222r23 are characterized by the fact that R21, R22, and R23 are independent hydrogen compounds, asphalts, alternative asphalts, cyclopropyl or cyclopropyl substitutes; or substitutes,R21 and R22 or R22 and R23, together with atoms, form an alternative heterocyclic substitution group; (d) - C (x2) - n (R3) cr2r2'c (= O) R1, characterized by x2 being selected from = O, = s and = N11, R11 being hydrogen or hydrocarbon, R1 being selected from - or7 and - n8r9, and R7 being selected from hydrogen, Asphalt, alternative asphalt, starch, starch, alternative, asphalt, alternative asphalt, alternative asphalt, alternative lime, isomerization, alternative isomerization, alternative recycling and alternative recycling; R8 and R9 are the same as the previous definitions; R2 and R2 'are independently selected from hydrogen, asphalt, alternative asphalt and halogen,Alternative calcium, asphalt, alternative asphalt, alternative asphalt, alternative arilo, alternative arilo, alternative arilo, alternative arilo, ring armour, alternative ring armour R2 and R2 'by definition, they are combined with transverse carbon atoms to form a cyclic electrolysis, alternative cyclic electrolysis, alternative cyclic or alternative alternative group, or more alternative R2 or R2' is hydrogen, asphalt or tar alternative group, and the other group is combined with transverse C atom. They,R7 and the side oxygen atom of the same or R8 and the side nitrogen atom of the same or R8 form an alternative heterocycle or heterocycle group; R3 is selected between hydrogen and tar, If R2 and R2 'do not form a ring together, and R2 or R2' and R7 or R8 do not combine to form an alternative group of heterocycles or heterocycles, R3, together with the nitroglycerin atom on its side, can form a heterocycle or heterocycle ring group together with R2 and R2 '. (e) - (c) (x2) - n (R3) cr25r26r27, characterized by the same definition of x2 and R3 as before, R25,The selection of R26 and R27 is independent of a group consisting of asphalt, alternative asphalt, arilo, alternative arilo, alternative heterocycle, alternative heterocycle, heteromorphic and heteromorphic, or a cyclopentyl, cyclopentyl alternative group consisting of R25 and R26 with their side carbon atoms, a. Alternative heterocycles or heterocycles; and (f) a carboxylic acid heterocholesterol, in which the heterocholesterol is not defined in (a) - (E).