Substituted piperidines and tetrahidropiranos as inhibitors of the activity of sglt2, a Pharmaceutical formulation that comprises a dosing unit which employs and its use in Lowering Blood Glucose and Treatment of related diseases.

摘要

Compounds and Pharmaceutical compositions are disclosed comprising the same and are useful for the treatment of diseases and disorders such as Diabetes and obesity.Claim 1: a compound of the formula (1) or its pharmaceutically acceptable salts or solvates, where a is optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heterocycle; X is o or NR1; where X is o, R1 is or1a, SR1a, sor1a, so2r1a or N (A1a ) 2, where X is or1a nr3, R1 is Hydrogen, SR1a, sor1a so2r1a,Or A1A A1A; each is independently Hydrogen or optionally substituted alkyl, optionally substituted aryl or Heterocyclic Fluorine or optionally substituted; R2 is or2a; each 2a R2B and R2c is independently Hydrogen, alkyl, optionally substituted alkyl, Optionally, C (o). Formed, C (or optionally substituted aryl or aryl) R3 is Hydrogen, optionally substituted;Co2r3a R3A, C (o), (r3b) 2, or optionally substituted alkyl, optionally substituted aryl or optionally substituted heterocycle R3A; each is independently alkyl or aryl optionally replaced optionally substituted; and each r3b is independently Hydrogen, alkyl, optionally Optionally substituted aryl or substituted.