A compound of Amorphous form of N - {2-fluoro-5 - 3 - (thiophene - 2 - carbonyl) pyrazolo 1, 5-a pyrimidine 7 - yl - phenyl) - n-methyl acetamide procedimientopara, their preparation, Pharmaceutical composition containing same and its use in manufacture of a Medicament for the treatment of disorders mediated by

摘要

Amorphous form of N - {2-fluoro-5 - [3 - (thiophene - 2 - carbonyl) pyrazolo [1,5-a] pyrimidine 7 - yl] - phenyl) - n-methyl acetamide, Methods for their preparation, their use as therapeutically ACTIVE AGENT and Pharmaceutical compositions that comprise.Claim 2: a procedure for the preparation of the compound as claimed in claim 1, characterized in that it comprises the steps of: (i) dissolution of N - {2-fluoro-5 - [3 - (thiophene - 2 - carbonyl) pyrazolo [1,5 to 7] - pyrimidine - yl] - phenyl) - n-methyl acetamide in dichloromethane; (ii) addition of carbon to the solution; (iii) heating the mixture to 30 - 50; (iv) stirring the mixture for 20 to 45 minutes; (V) Cooling of the suspension 15 - 30; (VI) Elimination by Filtration of Coal; vi (i) The Vacuum evaporation of the Solvent; and (viii) vacuum Drying to remove the remaining 40 - 60 degreesS of solvent.