Method for preparing inhibitor of Tryptase 4 - (2 - aminoethyl - 5 - fluoro - phenyl) - piperidin-1-yl - (4 - bromo - 3 - methyl - 5 - propoxy - thiophen-2-yl) methanone.

摘要

Claim 1: procedure for preparing [4 - (aminomethyl) - 2 - 5 - fluoro - phenyl) - 1il piperidin] - (4 '- bromo - 3 - methyl - 5 - propoxy - thiophen-2-yl) Meta Nona comprising coupling by imitating the Ester [- 1 - 2.5 - pyrrolidin-3-yl - ilo 4 - bromo acid - 3 - methyl - 2 - 5 - propoxitiofeno with hydrochloride acid 2 2Trifluoro - N - (2 - 3 - 4 - fluoro piperidin-4-yl IL - benzyl) - acetamide and a strong base or a base in a Tertiary Amine alcohol Solvent to produce 2,2,2 trifluoro - - n {- 3 - [1 - (4 - bromo - 3 - methyl - 5 - propoxy thiophene - 2 - carbonyl) piperidin-4-yl] - il - 4 - Benzyl - fluoro acetamide and Unprotect 2,2},2 - trifluoro - n {- 3 - [1 - (4 - bromo - 3 - methyl - 5 - propoxy thiophene - 2 - carbonyl) piperidin-4-yl] fluro - il - 4 - benzyl} acetamide with a base to produce - [4 - (aminomethyl) - 2 - 5 - fluoro - phenyl) - piperidin-1-yl] - (4 - bromo - 3 - methyl - 5 - propoxy - thiophen - 2 - il) methanone