Oxazolidinone Derivatives, Pharmaceutical Composition and use in Medicine, bacterial infections

摘要

Claim 1: A compound of formula 1 in which R1 is hydrogen, halogen, hydroxyl, alkoxy or cyano; Y1 and Y2 each represents CH and one or two of U, V, W and X represents (n) N and the remaining each represents CH or, in the case of X, can also represent CRa, and, in the case of W, can also represent CRb, or each of U, V, W, X, Y1 and Y2 represents CH or each of U, V, W, X and Y1 represents CH and Y2 represents N, or also one or, given that R1 is hydrogen, two of U, V, W, X, Y1 and Y2 represent (n) CRc and the remaining each represents CH; Ra represents halogen; Rb represents alkoxy, alkoxycarbonyl or alkoxyalkoxy; Rc, every time it appears,Independent representative of hydroxyl or oxy group; esch2ch (OH),CH2CH (NH2)CH (OH) chn2 or CH (NH2) CH2, B is CH2CH2, ch2nh or CONH, D is CH2, or a is CH2 (OH) CH2, or B is CH2CH2, ch2nh, n (R2) Co, CONH or n (R2) CH2 and D are CH2 or B is n (R2A) CH2 and D is CH2,Or a is ch (OH) ch (OH),B is ch2nh or CONH, or esch2, or a is CH2CH2, or B is CH2CH2, nr4ach2, ch2nr3, nhco, conr4, CH2O, CH (OH) CH2, CH2CH (OH),CH2 (nhr3a) CH2, CH2 or ch2ch2nh and D are CH2 or B is ch2nh, D is co, or a is CH2CH2, B is nr4bch2 or CH2CH2, and D is CH2 (OH),or A is CH = CH, B is CH2NR5, CONR6 or CH2O and D is CH2, or A is C ::: C, B is CH2NH and D is CO, or A is CH2CO, B is NHCH2 and D is CH2, or A is COCH2, B is CH2CH2 or CONH and D is CH2, or A is CH2N (R7) and either B is CH2CH2, COCH2 or CH2CH (OH) and D is CH2 or B is CH2CH2, or CH2CH (OH) and Des CH (OH) or CH (NH2),or A is CONH or CH2O, B is CH2CH2 and D is CH2, or A is NHCH2 and either B is CH2CH2 or CH2NH and D is CH2, or B is CH2NH and D is CO, or A is NHCO, B is CH ( R8) NH or CH2CH2 and D is CH2, or A is OCH2, B is CH2, CH2CH2, CH = CH or CONH and D is CH2; R2 is hydrogen or alkyl; R2a is hydrogen or alkyl; R3 is hydrogen, phenylalkyl, CO- (CH2) p-COOR3 ',(CH2) p-COOR3Acid or carbamate, or the same R3, is a substance that can be replaced once or twice with a hydroxyl group, P is the complete 1-4 and R3 'as hydrogen or tar; R3a is hydrogen, acid or alkyl; R4 is hydrogen or tar; R4A is hydrogen or (CH2) q-cour4a',Or R4A is also a kind of tar that can be replaced once or twice with hydroxyl group. Q4a is an integer from 1 to 4, R4A is a whole, which is hydrogen or tar; r4b is h or tar; R5 is hydrogen or acid; R6 is hydrogen, asphalt or phenyl; R7 is hydrogen or (CH2) r-coor7 ',Or R7 is also a kind of tar, which can be replaced once or twice by a group independently selected from hydroxyl, hydrogen halide, amino and dimethylamine. R is an integer from 1 to 4, R7 is hydrogen or tar, R8 is hydrogen or tar, and is one of the following formulas (2); Where Z is ch or N, q is o or s, or E is a phenyl group, consisting of halogenated, tar 1-3, propoxyc1-3, sulfur trifluoride and sulfur trifluoride, or a salt independently selected, and replaced once or twice in the target location and / or substitute respectively.