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1,2,3,4-tetrahydroquinoline derivative, pharmaceutical composition, use of a 1,2,3,4-tetrahydroquinoline derivative, and process for the preparation of compounds.
1,2,3,4-tetrahydroquinoline derivative, pharmaceutical composition, use of a 1,2,3,4-tetrahydroquinoline derivative, and process for the preparation of compounds.
Tetrahydroquinoline derivatives of formula (I), their salts and metabolically labile esters are new. R = halo, alkyl, alkoxy, NH2, mono- or dialkylamino, OH, CF3, OCF3, NO2, CN, SO2R2 or COR2; R1 = (CH2)nCN, CH=CHR3, (CH2)nNHCOCH2R4 or O(CH2)pNR5R6; R2 = OH, OMe, NH2, or mono- or dialkylamino; R3 = CN or COR7; R4 = alkoxy or NHCOR8; R5, R6 = H or alkyl; or NR5R6 = heterocyclyl; or R5 = H and R6 = COR9; R7 = alkoxy, amino or OH; R8 = H or optionally substituted alkyl, alkoxy, phenyl, heteroaryl or heterocyclyl; R9 = R8 or NR10R11; R10 = H or alkyl; R11 = optionally substituted alkyl, phenyl, heteroaryl, heterocyclyl or cycloalkyl; m = 0-2; n = 0-4; and p = 2-4.
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机译：式（I）的四氢喹啉衍生物，其盐和代谢不稳定的酯是新的。 R =卤素，烷基，烷氧基，NH2，单或二烷基氨基，OH，CF3，OCF3，NO2，CN，SO2R2或COR2; R1 =（CH2）nCN，CH = CHR3，（CH2）nNHCOCH2R4或O（CH2）pNR5R6; R 2 ＝ OH，OMe，NH 2或单或二烷基氨基; R3 = CN或COR7; R4 =烷氧基或NHCOR8; R5，R6 ＝ H或烷基;或NR5R6 =杂环基;或者R5 = H且R6 = COR9; R7 ＝烷氧基，氨基或OH; R8 ＝ H或任选取代的烷基，烷氧基，苯基，杂芳基或杂环基; R9 = R8或NR10R11; R 10 ＝ H或烷基; R11 ＝任选取代的烷基，苯基，杂芳基，杂环基或环烷基; m = 0-2; n = 0-4;并且p = 2-4。
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