gram-positive, noninvasive, non-pathogenic bacterium, DNA vector, method for heterologous production of complex capsular polysaccharides (cps) in a non-invasive, non-pathogenic, gram-positive bacterium and pharmaceutically acceptable composition

摘要

GRAM-POSITIVE BACTERIA, NON INVASIVE, PATHOGENIC NON, DNA VECTOR, METHOD FOR THE COMPLEX CAPSULAR POLYSACARIDE (1-IETEROGUE) PRODUCTION IN A GRAM-POSITIVE BACTERIA NACOTIC NAC, The present invention provides methods and means for the heterologous expression, production and / or secretion of complex capsular polysaccharides in non-pathogenic, noninvasive Gram-positive bacteria. The invention particularly provides non-invasive, non-pathogenic Gram-positive bacteria capable of expression and / or secretion of complex heterologous polysaccharides from a pathogenic bacterial species. These bacteria and polysaccharides produced in this manner may be applied according to the invention to provide vaccination compositions for the treatment and prevention of infectious bacterial diseases.