Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria

摘要

The current invention provides methods and means for heterologous expression, production and/or secretion of complex capsular polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria. The invention in particular provides non-pathogenic, non-invasive Gram-positive bacteria capable of expression and/or secretion of heterologous, complex polysaccharides from a pathogenic bacterial species. Such bacteria and polysaccharides produced therein may be applied according to the invention to provide compositions for vaccination for the treatment and prevention of infectious bacterial diseases.