methods for the resolution of 4- 4- (dimethylamino) -1- (4'-fluoro-phenyl) -1-hydroxy-butyl -3- (hydroxymethyl) -benzonitrile as a racemic or non-racemic mixture. of enanciomers in their isolated enanciomers and for the manufacture of escitalopram

摘要

METHODS FOR SOLVING 4- [4- (DIMETHYL-AMINO) -1- (4'-FLUORO-PHENYL) - 1-HYDROXY-butyl] -3- (HYDROXY-METHYL) -BENZONITRIL AS A RACEMIC OR NOT RACEMIC OF ENANCIEMEROS IN ITS ISOLATED ENANCIEMERS AND FOR MANUFACTURE OF ESCITALOPRAM. This patent describes a method for the resolution of 4- [4- (dimethylamino) -1- (4'-fluoro-phenyl) -1-hydroxy-butyl] -3- (hydroxymethyl) -benzonitrile as a mixture racemic or non-racemic of enanciomers in their isolated enanciomers, said method comprising the steps of fractionally crystallizing 4- [4- (dimethylamino) -1- (4'-fluoro-phenyl) -1-hydroxy-butyl] - 3- (hydroxymethyl) benzonitrile as a salt with the O, O'-di-p-toluoyl tartaric acid (+) - (S, S) or (R, R) -enanciomer in a solvent system comprising 1-propanol, ethanol or acetonitrile.