Transgenic mice used as a model for human pathologies originating in stem cells

摘要

Transgenic non-human mammals that reproduce the human pathology that is of stem cell origin, for example, chromosomal anomalies associated with chronic myeloid leukaemia, B-cell acute lymphoblastic leukaemia, T-cell acute lymphoblastic leukaemia, or with the migration of haematopoietic or embryonic stem calls, using as a strategy the expression of the genes involved in said pathology in human beings by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of useful compounds for the treatment and/or prevention of said diseases.