RECOMBINANT MODIFIED ANKARA OSPOVACCINE VIRUS (MVA), EXPRESSING HOMOLOGICAL SEQUENCE, BUILT INTO THE POXVIRAL GENE

摘要

This invention relates to a recombinant vector of the modified vaccinia virus Ankara (MVA), capable of expressing two or more homologous foreign sequences, which are obtained from different variants of the microorganism and which have a homology of 50% or higher. The invention further relates to a method for producing such a recombinant MVA virus and the use of said recombinant virus as a drug or vaccine. In addition, a method for influencing an immune response is proposed, preferably for inducing it in an animal, including a human.