HINAZOLIN DERIVATIVES AS MTKI

摘要

The present invention relates to compounds of formula (I), their N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms, where Y is —C-alkyl-, —C-alkyl-NR-C-alkyl- or —C-alkyl -HR-CO-C-alkyl-; X means -O-; X is NR-Calkyl; R is hydrogen, halogen or Het-O-; R is hydrogen; R represents a hydroxy group, a C-alkyloxy group or a C-alkyloxy group substituted with one or two substituents, each independently selected from Het, a hydroxy group, a C-alkyloxy group, a C-alkyloxy-C-alkyloxy group and NRR; R is hydrogen or C-alkyl; R is hydrogen or C-alkyl; R is hydrogen; R and R, each independently, are hydrogen, C-alkyl-S (= O) -Calkyl-C (= O) -; C-alkyl or C-alkyl substituted with hydroxy; Het means pyridinyl optionally substituted with C-alkyl; Het means morpholinyl, piperidinyl or piperazinyl, wherein said Het is optionally substituted with hydroxy-C-alkyl or C-alkyl-S (= O) -Calkyl.