HUMAN ANTIBODIES TO DELTA-LIKE HUMAN LIGAND-4

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention relates to biochemistry. Described is isolated human antibody or antibody fragment, which bind human delta-like ligand 4 (HDll4) in a specific way, said human antibody or antibody fragment contains heavy chain variable region (HCVR), which contains three complementarity-determining regions (CDR) of heavy chain, and light chain variable region (LCVR), which contains three CDR of light chain, where said three CDR of heavy chain contain CDR1, CDR2 and CDR3 sequences SEQ ID NO:429 or SEQ ID NO:901, and said three CDR of light chain contain CDR1, CDR2 and CDR3 sequences SEQ ID NO:437 or SEQ ID NO:903, and where said antibody or its fragment binds with epitope within N-end-DSL domain of hDll4. Described is isolated molecule of nucleic acid, coding described antibody or its antigen-binding fragment. Presented is expression vector, containing described nucleic acid molecule and system "host-vector" for obtaining described antibody. Described is composition for facilitation of course or inhibition of Dll4-mediated human disease or disorder, containing described antibody or its fragment.;EFFECT: claimed is method of obtaining described antibody against human Dll4 or its antigen-binding fragment.;25 cl, 16 tbl, 9 ex