Biologically Active compounds labeled with 18F fluoro benzoyl as agents of diagnosis by Images as well as precursors of benzotriazole - 1 - iloxi - Benzoyl - pyrrolidin-3-yl, 2.5 - - 1 - iloxi benzoyl benzoyl and trimethylammonium

摘要

The invention refers to a benzene substitute compound which is radiolabeled for diagnostic image. The present invention provides methods for the processing of these compounds, in particular the manufacture of new compounds as 18 f-labeled precursors, and the use of these 18 f-labeled compounds for image diagnosis. Formula (a)One of them - Y1, Y2, Y3, Y4 e-y5 is - a-b-d-p, wherein - a-b-d is a link or separator, P is a peptide, an anesthetic, an oligoribose or a small molecule, K is lg-ow, where lg-o-w is selected from formula group (b),In this case, t is h or Cl, q is ch or N, K is absent or C = O, W is a radioactive or non radioactive fluorine isotope, preferably 18F.