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A process for the preparation of a stable anhydrous anthelmintic formulation
A process for the preparation of a stable anhydrous anthelmintic formulation
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机译:一种稳定的无水驱虫制剂的制备方法
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摘要
The present invention is directed to an industrial scale process for preparing a stable anhydrous anthelmintic liquid formulation containing ivermectin. The process comprises the steps of purging the manufacturing vessel with nitrogen gas, altering the pressure of the manufacturing vessel, rinsing the manufacturing vessel with isopropyl alcohol, adding isopropyl alcohol, Ivermectin and a fatty acid ester emollient, mixing, testing the solution, adding a buffering agent mixing, testing the solution, making up the total volume of the solution to 100% v/v with isopropyl alcohol and mixing and packaging the formulation. The formulation of the present invention is used for topical administration as a pour-on formulation.
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