HUMAN NOTCH AND DELTA, BINDING DOMAINS IN TOPORYTHMIC¹PROTEINS, AND METHODS BASED THEREON

摘要

The present invention provides substantially purified fragments of a Delta protein as well as derivatives and analogs thereof, characterized by the ability in vitro, when expressed on the surface of a first cell to bind to a Notch protein, or a second Delta protein or fragment expressed on the surface of a second cell, the nucleic acid sequences encoding said fragments as well as vectors and recombinant cells containing the same. A method of producing a fragment of a Delta protein is also disclosed. IMAGE