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METHOD OF GENETIC TESTING FOR DETERMINING THE RISK OF POUCHITIS DEVELOPMENT
METHOD OF GENETIC TESTING FOR DETERMINING THE RISK OF POUCHITIS DEVELOPMENT
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机译:遗传测试方法确定粉刺发育的风险
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摘要
The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon η receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon η receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon η receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon η receptor 1 gene, such as a FA1 microsatellite 171 allele.
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