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MATERIALS AND METHODS FOR ALTERING AN IMMUNE RESPONSE TO EXOGENOUS AND ENDOGENOUS IMMUNOGENS, INCLUDING SYNGENEIC AND NON-SYNGENEIC CELLS, TISSUES OR ORGANS
MATERIALS AND METHODS FOR ALTERING AN IMMUNE RESPONSE TO EXOGENOUS AND ENDOGENOUS IMMUNOGENS, INCLUDING SYNGENEIC AND NON-SYNGENEIC CELLS, TISSUES OR ORGANS
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机译:改变对外源性和内源性免疫原性免疫反应的材料和方法,包括同种和非同种细胞,组织或器官
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摘要
Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reactien to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogenous or stimuli, as well as ameliorates an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immnnological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immnnogenicity.
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