A PROCESS FOR THE PREPARATION OF A NOVEL 3-TETRAHYDRO-2H-2-PYRANYLOXY-5-(TERT.BUTYLDIMETHYLSILYLOXY)-(1S,3R,5R)-CYCLOHEXAN-1-OL USEFUL AS AN INTERMEDIATE FOR ß-HYDROXY γ-LACTONE'

摘要

A process for the preparation of a novel3-tetrahydro-2H-2-pyranyloxy-5-(tert.butyldimethylsilyloxy)-(1S,3R,5R)-cyclohexan-1-ol useful as an intermediate for j3-hydroxy y-lactone by reacting a compound 3-tetrahydro-2H-2-pyranyloxy-5-(tert.butyldimethylsilyloxy)-(1S,3R,5R)-cyclohexylacetate (6) with an anhydrous potassium carbonate in an organic solvent at room temperature ranging for a period from 2 to 6 hrs, evaporating the solvent, extracting with organic solvent, washing with brine solution, drying, evaporating and column chromatography to obtain 3-tetrahydro-2H-2-pyranyloxy-5-(tert.butyl-dimethylsilyloxy)-(1S,3R,5R)-cyclohexan-1-ol (7).