A PROCESS FOR THE ISOLATION OF CRYSTALS OF OPTIONALLY SUBSTITUTED 2-(2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLE HYDRATES

摘要

"A PROCESS FOR THE ISOLATION OF CRYSTALS OF OPTIONALLY SUBSTITUTED 2-(2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLE HYDRATES" A process for the isolation of crystals of optionally substituted 2-(2-pyridinyl)methylthio-lH-benzimidazole hydrates of the following structural formula I in which R1, R2 and R3, identical or different, denote hydrogen, a C1—C8 alkyl, C3-C8 cycloalkyl, C2-C8 fluoroalkyl or C1-C8 alkoxy, R4 and R5, identical or different, denote hydrogen, a C1-C8 alkyl, C3-C8 cycloalkyl, CH2- C3—C8 cycloalkyl, C1-C8 alkoxycarbonyl, C1-C8 alkoxy, C1-C8 fluoroalkoxy, CF3-, C2-C8 fluoroalkyl or C(O)O-C1-C8 alkyl and R6 denotes hydrogen or a C1-C2 alkyl and x means 0.5-2; wherein said process comprises isolation from a reaction medium as herein described containing the free base, characterized in that a water-soluble, organic solvent present in the reaction medium is at most partially removed, water is added to the reaction medium at a temperature of below 40°C water in quantities of at least 55 wt.%, relative to the reaction medium, and the hydrates formed are separated as crystals and optionally purified in conventional manner.