A COMBINATION COMPRISING ATLEAST ONE TREATMENT MODALITY AND A PURIFIED HSP

摘要

The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an &agr;-2-macro globulin (&agr;2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an &agr;2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or &agr;2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.