A NUCLEIC ACID DIRECTING THE EXPRESSION OF A PROTEIN OF INTEREST IN THE CELLS OF THE POSTERIOR SERICIGENIC GLANDS OF BOMBYX MORI

摘要

A nucleic acid directing the expression of a protein of interest specifically in the cells of the posterior sericigenic glands of Bombyx mori, wherein said nucleic acid comprises, from the 5' terminus to the 3' terminus, (i) a regulatory region comprising regulatory signals for the expression of a polynucleotide of interest specifically in said sericigenic cells and (ii) a region coding for a modified signal peptide placed under the control of said regulatory region, said nucleic acid having at least 90 % identity in nucleotides with the polynucleotide running from nucleotide 1150 to nucleotide 2026 of the sequence SEQ ID NO: 1 and in which the trinucleotide running from the nucleotide 1486 to nucleotide 1488 of sequence SEQ ID NO: 1 codes for an amino acid chosen from the group comprising alanine, isoleucine and leucine.