A PROCESS FOR THE PREPARATION OF 4-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)HYDROXY(1-METHYL-1H-IMIDAZOL-5-Y1)METHYL-1-METHYL-2(1H-QUINOLINONE (III) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

"A process for the preparation of 4-(3-chlorophenyl)-6-[(4- chlorophenyl)hydroxy( 1 -methyl- lH-imidazol-5-yl)methyl]-1 -me thyl-2( 1H- quinolinone (III) and its pharmaceutically acceptable salts" A process for the preparation of 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy( 1 -methyl-1 H-imidazol-5-yl)methyl]-1 -methyl-2 (1H-quinolinone (III) and its pharmaceutically acceptable salts: which comprises reacting 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-l-methyl-2(l-H)- quinolinone (II): with a hexyllithium compound, 1-methylimidazole and a tributylsilyl halide, the reaction being effected at a temperature of at least -20°C.