Payrazoles as Inhibitors of Tumor ‎Necrosis Factor.‎

摘要

The present invention provides ‎compounds of Formula (I)‎ And ester prodrugs, pharmaceutically ‎acceptable salts or solvates of such ‎compounds; or ester prodrugs of such ‎salts or solvated; pharmaceutical ‎compositions comprising such ‎compounds, their preparation, and their ‎pharmaceutical use in the treatment of ‎disease states capable of being ‎modulated by the inhibition of p38 ‎kinase and/ or tumor necrosis factor ‎‎(TNF).‎