the present invention relates to novel sirna comprising a sense strand rna isolated and antisense rna strand complementary, together forming a duplex rna.characterized in that it includes a sense strand of rna nucleotide sequence which has more distinct compared with a fragment of 14 to 30 nucleotides in the nucleotide sequence of the adjacent exon f protein gene of myosin va, as well as compositions containing at least one sirna.and the use of at least one cosmetic or therapeutic sirna as an agent for the depigmentation of the skin.
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