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PELLETS COMPRISING AN ACTIVE SUBSTANCE MATRIX RESISTANT TO GASTRIC JUICE.
PELLETS COMPRISING AN ACTIVE SUBSTANCE MATRIX RESISTANT TO GASTRIC JUICE.
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机译:颗粒包含抗胃液的活性物质基质。
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摘要
The invention relates to pellets having a mean particle size of between 300 and 1100 µm, containing a pharmaceutically active substance integrated into a polymer matrix consisting of at least one water-insoluble polymer. The invention is characterised in that the polymer matrix also contains between 10 and 90 wt. % of an anionic polymer, in the release test according to USP, provided that the pellets release no more than 10 % of the active substance in the artificial gastric juice at a pH of 1.2 after 120 min, and release at least 50 % of the active substance after a total of another 300 min at a pH of 6.8 and/or 7.5.
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