Use of N - fenilamidas acid 2 - sulfonilaminobenzoico with sulfonyl substituted in the treatment of Pain

摘要

Refers to a compound of formula I, where a is not fenilenosustituido or c1-c4 alkyl, halogeno, trifluoromethyl; r1 is r7r8n, Het; R2 is not replaced by phenyl or heteroaryl c1-c4 alkyl, halogen, Nitro, cyano, trifluoromethyl, R3, R4, R5 and R6 are each h, c1-c4 alkyl, trifluoromet ILO, cyano, among others; R7 is H, c1-c4 alkyl, alquenilo c3-c5; R8 is c1-c4 alkyl,Cycloalkyl C3 - C7, indenilo, among others; Het is Aromatic heterocycle of 5-6 members containing heteroatoms in Ring 1 - 2, the same or different.Preferred compounds are: hydrochloride (2 - 5 - Chloro - thiophene - 2 - 4.5 - Dimethoxy - sulfonylamino) - N - (4 - (n-methyl-n - (pyridin-3-yl) - methyl) - aminosulfonil) - phenyl) - benzamide; 3 - methyl - 2 - (4 - clro - phenylsulfonylamino) - N - (4 - (N - methyl - N - (2 - (pyridin-2-yl) - ethyl) - aminosulfonil) - phenyl) - benzamide; among others. These compounds are useful in the treatment of Pain associated with chronic musculoskeletal disease