Pirrolo compounds 3,2-d pyrimidine and their use as inhibitors of PI3 Kinase and mTOR kinase

摘要

Refers to a compound of formula I, wherein R1 is alkyl substituted C1 - C6 or not, alquenilo C2 - C6 substituted aryl - No, C6 to C14, among others; is CH2O -, - O -, - S, - S (or S) - 2 - (OR); M is 0 - 2; R2 is C1 - C6 substituted Halogen, alkyl or alkoxy, substituted or unsubstituted C1 - C6, alquenilo C2 - C6, among others. Is 1 to 5; R3 and R4 are each H c1-c6 alkyl, substituted or unsubstituted, alquenilo C2 - C6, alquinilo C2 - C6Among others, R5 is preferably H. compounds are preferred: 2 - [3 - (Benzyloxy) - phenyl] - 4 - (4 - il5h pyrrolo [3,2-d] pyrimidine; {- 4 - (3 - [4 - (IL - 7 - methyl - 1 - pyrrolidin-3-yl) - 5H - pirrolo [3,2-d] pyrimidine 2 - phenyl Methanol il]}; {3 - [4 - (1 - Benzyl - - 1,2,3,6 tetrahidropiridin - 4-yl) - 4 - (4 - il - 5h pyrrolo [3 2 - d] pyrimidine 2 - il] phenyl) methanol; among others.These compounds are useful as PI3K and mTOR Inhibitors carcinostaticos agents