Pharmacodynamic binding includes antagonism to progesterone receptor and antiestrogen

摘要

IT REFERS TO PHARMACEUTICAL COMPOSITIONS THAT INCLUDE: a) 11B- (4-ACETILFENIL) -17B-HIDROXI-17A- (1,1,2,2,2-PENTAFLUOROETIL) -ESTRA-4,9-DIEN-3-ONA, OR AN ANALOG; b) A PURE ANTIESTROGEN, SUCH AS I, WHERE Hal IS F O Cl, AND WHICH IS ATTACHED TO THE STRATRENE SKELETON IN POSITION 11B; R3 IS H, (C1-C4) ALKYL, (C1-C4) ALCANYL OR A (C3-C7) CYCLE ETHER WITH AN ATOM OF O; R17 'IS H, (C1-C4) ALKYL OR (C1-C4) ALKYLNYL; R17 '' IS (C1-C4) ALKYL, (C1-C4) ALKYNYL; SK IS THE GROUP U-V-W-X-Y-Z-E THAT IS ATTACHED TO THE STRATRIENE SKELETON THROUGH U IN POSITION 7A; U IS (C1-C13) ALKYLENE OR -ALKENYLENE; V IS CH2-O C (O);W is n (R6),N + (o -) (R6) group,AN AZOLIDINYLENE N-OXIDE RING, AMONG OTHERS; R6 IS H, CH2-R7 O C (O) -R7; R7 IS H, (C1-C14) ALKYL, (C3-C10) CYCLLOALKYL, AMONG OTHERS; X IS (C1-C12) ALKYLENE, ALKYLENE OR ALKYLENE; AND IT IS A DIRECT LINK, (C3-C10) CICLOALQUILO, (C7-C20) ARALQUILO, AMONG OTHERS; Z IS A DIRECT LINK, (C1-C9) ALKYLENE, ALKYLENE OR ALKYLENE; E IS A GROUP CF3 OR A GROUP ARILO PARTIALLY FLOWERED; 11B-FLUORO-17A-METHYL-7A- {5- [METHYL- (8,8,9,9,9-PENTAFLUORONONYL) AMINO] PENTIL} -ESTRA-1,3,5 (10) -TRIEN-3 ARE SELECTED , 17B-DIOL, 7A- [9- (4,4,5,5,5-PENTAFLUOROPENTIL-SULFINIL) -NONIL] -ESTRA-1,3,5 (10) -TRIEN-3,17 BETA-DIOL,There are others He also mentioned a preparatory process These compounds contribute to the treatment and / or prevention of gastric cancer, breast cancer, sclerosis, polio, etc.