Messina modulated isomerization compounds

摘要

It's an abiotic formula compound,Among them, W1 and W2 are cr11r12, nr13, O; W3 is cr1r2, nr14, O; R1, R2, R11 and R12 are h, oh, carboxi, sulanilo, sulfur, etc.; R13 and R14 are h, C1-C20, alquenilo c2-c20, etc.; Z1 is 5 to 7 members, 1 to 3 are n, or 3 to 7 are heterosexual or 3 to 3 are heterosexual. Z2 is arilo, which is composed of 5 to 7 members, 1 to 3 N, O and s heterosexuals or heterosexuals, 3 to 7 members, which is composed of 1 to 3 o, s and N heterosexuals; R3, R4, R5 and R6 are h, oh, carboxi, sulfur, etc.; R7 and R10 are h, oh, CN, halo, etc.; R8 is h, C1-C20, cycloquilo, etc.; m and P are integers 0 to 3;N is an integer of 0 to 4; q is an integer of 1 to 4. - 4-4, methyl (4-4-4-4), methyl (4-4-4-4-4-5-5-4), methyl (4-4-4-4), er {1 - (2-aminocetil) - 4 - [(n - (2-tienil) carbomobiloxi) methyl] (4-piperidil)} - N - [(2-chlorophenyl) methyl] carboxamida, etc. A pharmaceutical composer was also mentioned These compounds can regulate smooth and / or non muscle skin and can be used to treat hypertension, asthma, glaucoma, abscess, etc.